关键词 |
一抗 |
面向地区 |
剂型 |
其他 |
中文名称: 兔抗ITCH(Ab-420) 多克隆抗体
英文名称:Anti-ITCH(Ab-420) rabbit polyclonal antibody
别 名: AIF4; AIP4; ADMFD; NAPP1; dJ468O1.1
储 存: 冷冻(-20℃) 避光
抗 原: ITCH(Ab-420)
宿 主: Rabbit
反应种属:Human Mouse
相关类别:一抗
标记物: Unconjugate
克隆类型:Unconjugate
技术规格
Background: | Acts as an E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. It catalyzes 'Lys-29'-, 'Lys-48'- and 'Lys-63'-linked ubiquitin conjugation. It is involved in the control of inflammatory signaling pathways. Is an essential component of a ubiquitin-editing protein complex, comprising also TNFAIP3, TAX1BP1 and RNF11, that ensures the transient nature of inflammatory signaling pathways. Promotes the association of the complex after TNF stimulation. Once the complex is formed, TNFAIP3 deubiquitinates 'Lys-63' polyubiquitin chains on RIPK1 and catalyzes the formation of 'Lys-48'-polyubiquitin chains. This leads to RIPK1 proteasomal degradation and consequently termination of the TNF- or LPS-mediated activation of NFKB1. Ubiquitinates RIPK2 by 'Lys-63'-linked conjugation and influences NOD2-dependent signal transduction pathways. Regulates the transcriptional activity of several transcription factors, and probably plays an important role in the regulation of immune response. Ubiquitinates NFE2 by 'Lys-63' linkages and is implicated in the control of the development of hematopoietic lineages. Critical regulator of T-helper (TH2) cytokine development through its ability to induce JUNB ubiquitination and degradation By similarity. Ubiquitinates SNX9. Ubiquitinates CXCR4 and HGS/HRS and regulates sorting of CXCR4 to the degradative pathway. It is involved in the negative regulation of MAVS-dependent cellular antiviral responses. Ubiquitinates MAVS through 'Lys-48'-linked conjugation resulting in MAVS proteasomal degradation. Involved in the regulation of apoptosis and reactive oxygen species levels through the ubiquitination and proteasomal degradation of TXNIP. Mediates the antiapoptotic activity of epidermal growth factor through the ubiquitination and proteasomal degradation of p15 BID. Targets DTX1 for lysosomal degradation and controls NOTCH1 degradation, in the absence of ligand, through 'Lys-29'-linked polyubiquitination. |
Applications: | WB |
Name of antibody: | ITCH(Ab-420) |
Immunogen: | Synthesized non-phosphopeptide derived from human ITCH around the phosphorylation site of tyrosine 420 (F-I-Y(p)-G-N). |
Full name: | itchy E3 ubiquitin protein ligase |
Synonyms: | AIF4; AIP4; ADMFD; NAPP1; dJ468O1.1 |
SwissProt: | Q96J02 |
WB Predicted band size: | 103 kDa |
WB Positive control: | Mouse brain tissue lysate |
WB Recommended dilution: | 500-3000 |
上海通蔚实业有限公司位于中国率先大城市——中华人民共和国直辖市之一的上海,且依托上海张江高科生物研究优势,主要是一家经营elisa试剂盒、检测试剂盒、酶联检测试剂盒等产品的厂家,目前已发展成集科研、生产、销售为一体的创新性企业。