关键词 |
一抗 |
面向地区 |
剂型 |
其他 |
中文名称:兔抗RAD17多克隆抗体
英文名称:Anti-RAD17 rabbit polyclonal antibody
别 名: CCYC; R24L; RAD24; HRAD17; RAD17SP
相关类别:一抗
储 存: 冷冻(-20℃)
宿 主: Rabbit
抗 原: RAD17
反应种属:Human, Mouse
标记物: Unconjugate
克隆类型:rabbit polyclonal
技术规格
Background: | The protein encoded by this gene is highly similar to the gene product of Schizosaccharomyces pombe rad17, a cell cycle checkpoint gene required for cell cycle arrest and DNA damage repair in response to DNA damage. This protein shares strong similarity with DNA replication factor C (RFC), and can form a complex with RFCs. This protein binds to chromatin prior to DNA damage and is phosphorylated by the checkpoint kinase ATR following damage. This protein recruits the RAD1-RAD9-HUS1 checkpoint protein complex onto chromatin after DNA damage, which may be required for its phosphorylation. The phosphorylation of this protein is required for the DNA-damage-induced cell cycle G2 arrest, and is thought to be a critical early event during checkpoint signaling in DNA-damaged cells. Multiple alternatively spliced transcript variants of this gene, which encode four distinct protein isoforms, have been reported. Two pseudogenes, located on chromosomes 7 and 13, have been identified. |
Applications: | ELISA, WB |
Name of antibody: | RAD17 |
Immunogen: | Fusion protein of human RAD17 |
Full name: | RAD17 checkpoint clamp loader component |
Synonyms: | CCYC; R24L; RAD24; HRAD17; RAD17SP |
SwissProt: | O75943 |
ELISA Recommended dilution: | 1000-2000 |
WB Predicted band size: | 77 kDa |
WB Positive control: | Lovo cells |
WB Recommended dilution: | 200-1000 |