兔抗DIO2多克隆抗体

Background:

The protein encoded by this gene belongs to the iodothyronine deiodinase family. It activates thyroid hormone by converting the prohormone thyroxine (T4) by outer ring deiodination (ORD) to bioactive 3,3',5-triiodothyronine (T3). It is highly expressed in the thyroid, and may contribute significantly to the relative increase in thyroidal T3 production in patients with Graves disease and thyroid adenomas. This protein contains selenocysteine (Sec) residues encoded by the UGA codon, which normally signals translation termination. The 3' UTR of Sec-containing genes have a common stem-loop structure, the sec insertion sequence (SECIS), which is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. Alternative splicing results in multiple transcript variants encoding different isoforms.

Applications:

ELISA, WB

Name of antibody:

DIO2

Immunogen:

Synthetic peptide of human DIO2

Full name:

deiodinase, iodothyronine, type II

Synonyms：

D2; 5DII; SelY; DIOII; TXDI2

SwissProt:

Q92813

ELISA Recommended dilution:

1000-2000

WB Predicted band size:

31 kDa

WB Positive control:

Mouse brain tissue

WB Recommended dilution:

200-1000