兔抗BAD(Phospho-Ser91128)多克隆抗体

Background:

The protein encoded by BAD gene is a member of the BCL-2 family. BCL-2 family members are known to be regulators of programmed cell death. This protein positively regulates cell apoptosis by forming heterodimers with BCL-xL and BCL-2, and reversing their death repressor activity. Proapoptotic activity of this protein is regulated through its phosphorylation. Protein kinases AKT and MAP kinase, as well as protein phosphatase calcineurin were found to be involved in the regulation of this protein. Alternative splicing of this gene results in two transcript variants which encode the same isoform.

Applications:

WB, IHC

Name of antibody:

BAD(Phospho-Ser91/128)

Immunogen:

Peptide sequence around phosphorylation site of Serine 91 (E-P-S(p)-P-F) derived from Human BAD or Serine 128 (E-P-S(p)-P-F) derived from Mouse BAD.

Full name:

BCL2-associated agonist of cell death

Synonyms：

BBC2; BCL2L8

SwissProt:

Q92934

IHC positive control:

Human breast carcinoma tissue

IHC Recommend dilution:

50-100

WB Predicted band size:

18 kDa

WB Positive control:

COS7 cells lysates treated with TNF-a

WB Recommended dilution:

500-1000