兔抗ACVR1多克隆抗体

Background:

Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I ( I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. This gene encodes activin A type I receptor which signals a particular transcriptional response in concert with activin type II receptors. Mutations in this gene are associated with fibrodysplasia ossificans progressive.

Applications:

ELISA, WB

Name of antibody:

ACVR1

Immunogen:

Synthetic peptide of human ACVR1

Full name:

activin A receptor type I

Synonyms:

FOP; ALK2; SKR1; TSRI; ACTRI; ACVR1A; ACVRLK2

SwissProt:

Q04771

ELISA Recommended dilution:

2000-5000

WB Predicted band size:

57 kDa

WB Positive control:

NIH/3T3 and HUVEC cell lysates

WB Recommended dilution:

200-1000