兔抗ENSA多克隆抗体

Background:

The protein encoded by this gene belongs to a highly conserved cAMP-regulated phosphoprotein (ARPP) family. This protein was identified as an endogenous ligand for the sulfonylurea receptor, ABCC8/SUR1. ABCC8 is the regulatory subunit of the ATP-sensitive potassium (KATP) channel, which is located on the plasma membrane of pancreatic beta cells and plays a key role in the control of insulin release from pancreatic beta cells. This protein is thought to be an endogenous regulator of KATP channels. In vitro studies have demonstrated that this protein modulates insulin secretion through the interaction with KATP channel, and this gene has been proposed as a candidate gene for type 2 diabetes. At least eight alternatively spliced transcript variants encoding distinct isoforms have been observed.

Applications:

ELISA, IHC

Name of antibody:

ENSA

Immunogen:

Fusion protein of human ENSA

Full name:

endosulfine alpha

Synonyms:

ARPP-19e

SwissProt:

O43768

ELISA Recommended dilution:

5000-10000

IHC positive control:

Human liver cancer and Human cervical cancer

IHC Recommend dilution:

40-200