兔抗KDM2A多克隆抗体

Background:

Lysine-specific dease 1 (LSD1; also known as AOF2 and BHC110) is a nuclear amine oxidase homolog that acts as a histone delase and transcription cofactor. Gene activation and repression is specifically regulated by the lation state of distinct histone protein lysine residues. For example, lation of histone H3 at Lys4 facilitates transcriptional activation by coordinating the recruitment of BPTF, a component of the NURF chromatin remodeling complex, and WDR5, a component of multiple histone ltransferase complexes. In contrast, lation of histone H3 at Lys9 facilitates transcriptional repression by recruiting HP1. LSD1 is a component of the CoREST transcriptional co-repressor complex that also contains CoREST, CtBP, HDAC1 and HDAC2. As part of this complex, LSD1 delates mono-l and di-l histone H3 at Lys4 through a FAD-dependent oxidation reaction to facilitate neuronal-specific gene repression in non-neuronal cells. In contrast, LSD1 associates with androgen receptor in human prostate cells to delate mono-l and di-l histone H3 at Lys9 and facilitate androgen receptor-dependent transcriptional activation. Therefore, depending on gene context LSD1 can function as either a transcriptional co-repressor or co-activator. LSD1 activity is inhibited by the amine oxidase inhibitors pargyline, deprenyl, clorgyline and tranylcypromine.

Applications:

WB

Name of antibody:

KDM1A

Immunogen:

Fusion protein of human KDM1A

Full name:

lysine (K)-specific dease 1A

Synonyms：

KDM1; AOF2; BHC110; KIAA0601; LSD1; KDM1A

SwissProt:

O60341

WB Predicted band size:

95 kDa

WB Positive control:

SW480 and PC-3 cells

WB Recommended dilution:

500-2000