兔抗ITGB3(Phospho-Tyr785)多克隆抗体

Background:

Integrin alpha-V/beta-3 is a receptor for cytotactin, fibronectin, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin, vitronectin and von Willebrand factor. Integrin alpha-IIb/beta-3 is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. Integrins alpha-IIb/beta-3 and alpha-V/beta-3 recognize the sequence R-G-D in a wide array of ligands. Integrin alpha-IIb/beta-3 recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain. Following activation integrin alpha-IIb/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen. This step leads to rapid platelet aggregation which physically plugs ruptured endothelial surface. In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions.

Applications:

WB

Name of antibody:

ITGB3 (Phospho-Tyr785)

Immunogen:

Synthetic peptide of human ITGB3 (Phospho-Tyr785)

Full name:

integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) (Phospho-Tyr785)

Synonyms：

GT; CD61; GP3A; BDPLT2; GPIIIa; BDPLT16

SwissProt:

P05106

WB Predicted band size:

87 kDa

WB Positive control:

HUVEC cells

WB Recommended dilution:

500-1000