兔抗CLDN3(Phospho-Tyr219)多克隆抗体

Background:

Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. These junctions are comprised of sets of continuous networking strands in the outwardly facing cytoplasmic leaflet, with complementary grooves in the inwardly facing extracytoplasmic leaflet. The protein encoded by this intronless gene, a member of the claudin family, is an integral membrane protein and a component of tight junction strands. It is also a low-affinity receptor for Clostridium perfringens enterotoxin, and shares aa sequence similarity with a putative apoptosis-related protein found in rat. [provided by RefSeq, Jul 2008]

Applications:

WB

Name of antibody:

CLDN3(Phospho-Tyr219)

Immunogen:

Peptide sequence around phosphorylation site of tyrosine 219 (R-K-D-Y(p)-V) derived from Human Claudin 3.

Full name:

claudin 3

Synonyms：

RVP1; HRVP1; C7orf1; CPE-R2; CPETR2

SwissProt:

O15551

WB Predicted band size:

23 kDa

WB Positive control:

COLO cells lysates treated with EGF

WB Recommended dilution:

500-1000