兔抗ZAP70多克隆抗体

Background:

This gene encodes an enzyme belonging to the protein tyrosine kinase family, and it plays a role in T-cell development and lymphocyte activation. This enzyme, which is phosphorylated on tyrosine residues upon T-cell antigen receptor (TCR) stimulation, functions in the initial step of TCR-mediated signal transduction in combination with the Src family kinases, Lck and Fyn. This enzyme is also essential for thymocyte development. Mutations in this gene cause selective T-cell defect, a severe combined immunodeficiency disease characterized by a selective absence of CD8-positive T-cells. Two transcript variants that encode different isoforms have been found for this gene.

Applications:

ELISA, WB, IHC

Name of antibody:

ZAP70

Immunogen:

Fusion protein of human ZAP70

Full name:

zeta chain of T cell receptor associated protein kinase 70

Synonyms:

SRK; STD; TZK; STCD; IMD48; ADMIO2; ZAP-70

SwissProt:

P43403

ELISA Recommended dilution:

5000-10000

IHC positive control:

Human cervical cancer

IHC Recommend dilution:

50-300

WB Predicted band size:

70 kDa

WB Positive control:

Mouse liver tissue and Jurkat cell lysates

WB Recommended dilution:

500-2000