兔抗ABCA4多克隆抗体

Background:

The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intracellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ABC1 subfamily. Members of the ABC1 subfamily comprise the only major ABC subfamily found exclusively in multicellular eukaryotes. This protein is a retina-specific ABC transporter with N-retinylidene-PE as a substrate. It is expressed exclusively in retina photoreceptor cells, indicating the gene product mediates transport of an essental molecule across the photoreceptor cell membrane. Mutations in this gene are found in patients diagnosed with Stargardt disease, a form of juvenile-onset macular degeneration. Mutations in this gene are also associated with retinitis pigmentosa-19, cone-rod dystrophy type 3, early-onset severe retinal dystrophy, fundus flavimaculatus, and macular degeneration age-related 2.

Applications:

ELISA, IHC

Name of antibody:

ABCA4

Immunogen:

Synthetic peptide of human ABCA4

Full name:

ATP-binding cassette, sub-family A (ABC1), member 4

Synonyms：

FFM; RMP; ABCR; RP19; STGD; ABC10; ARMD2; CORD3; STGD1

SwissProt:

P78363

ELISA Recommended dilution:

2000-5000

IHC positive control:

Human cervical cancer and Human thyroid cancer

IHC Recommend dilution:

50-200