兔抗CAPN10多克隆抗体

Background:

Calpains represent a ubiquitous, well-conserved family of calcium-dependent cysteine proteases. The calpain proteins are heterodimers consisting of an invariant small subunit and variable large subunits. The large catalytic subunit has four domains: domain I, the N-terminal regulatory domain that is processed upon calpain activation; domain II, the protease domain; domain III, a linker domain of unknown function; and domain IV, the calmodulin-like calcium-binding domain. This gene encodes a large subunit. It is an atypical calpain in that it lacks the calmodulin-like calcium-binding domain and instead has a divergent C-terminal domain. It is similar in organization to calpains 5 and 6. This gene is associated with type 2 or non-insulin-dependent diabetes mellitus (NIDDM), and is located within the NIDDM1 region. Multiple alternative transcript variants have been described for this gene.

Applications:

ELISA, WB

Name of antibody:

CAPN10

Immunogen:

Synthetic peptide of human CAPN10

Full name:

calpain 10

Synonyms:

CANP10; NIDDM1

SwissProt:

Q9HC96

ELISA Recommended dilution:

5000-10000

WB Predicted band size:

75 kDa

WB Positive control:

A172 and 293T cell lysates

WB Recommended dilution:

200-1000