关键词 |
一抗 |
面向地区 |
剂型 |
其他 |
中文名称: 兔抗HTT多克隆抗体
英文名称:Anti-HTT rabbit polyclonal antibody
别 名: huntingtin; HD; IT15; LOMARS
相关类别:一抗
储 存: 冷冻(-20℃)
宿 主: Rabbit
抗 原: HTT
反应种属:Human, Rat
标记物: Unconjugate
克隆类型:rabbit polyclonal
技术规格
Background: | Huntingtin is a disease gene linked to Huntington's disease, a neurodegenerative disorder characterized by loss of striatal neurons. This is thought to be caused by an expanded, unstable trinucleotide repeat in the huntingtin gene, which translates as a polyglutamine repeat in the protein product. A fairly broad range of trinucleotide repeats (9-35) has been identified in normal controls, and repeat numbers in excess of 40 have been described as pathological. The huntingtin locus is large, spanning 180 kb and consisting of 67 exons. The huntingtin gene is widely expressed and is required for normal development. It is expressed as 2 alternatively polyadenylated forms displaying different relative abundance in various fetal and adult tissues. The larger transcript is approximately 13.7 kb and is expressed predominantly in adult and fetal brain whereas the smaller transcript of approximately 10.3 kb is more widely expressed. The genetic defect leading to Huntington's disease may not necessarily eliminate transcription, but may confer a new property on the mRNA or alter the function of the protein. One candidate is the huntingtin-associated protein-1, highly expressed in brain, which has increased affinity for huntingtin protein with expanded polyglutamine repeats. This gene contains an upstream open reading frame in the 5' UTR that inhibits expression of the huntingtin gene product through translational repression. |
Applications: | ELISA, IHC |
Name of antibody: | HTT |
Immunogen: | Synthetic peptide of human HTT |
Full name: | huntingtin |
Synonyms: | HD; IT15; LOMARS |
SwissProt: | P42858 |
ELISA Recommended dilution: | 5000-10000 |
IHC positive control: | Human tonsil and Human gastric cancer |
IHC Recommend dilution: | 40-200 |
主营行业:试剂盒 |
公司主营:elisa试剂盒,检测试剂盒,酶联检测试剂盒厂家,试剂盒批发--> |
主营地区:上海 |
企业类型:有限责任公司 |
公司成立时间:2010-01-01 |
员工人数:5 - 10 人 |
研发部门人数:5 - 10 人 |
经营模式:生产+贸易型 |
经营期限:1949-01-01 至 2031-01-01 |
最近年检时间:2020年 |
年营业额:人民币 10 万元/年以下 |
年出口额:人民币 10 万元/年以下 |
年进口额:人民币 10 万元/年以下 |
是否提供OEM:是 |
公司邮编:201500 |
公司电话:021-54845833 |
公司邮箱:2881498548@qq.com |
公司网站:http://www.tw-reagent.com |