兔抗OLFM1多克隆抗体

Background:

The Olfactomedin family comprises a diverse group of secreted glycoproteins, which includes OLFM1 (Noelin-1), OLFM2 (Noelin-2), OLFM3 (Noelin-3), OLFM4 (Noelin-4), tiarin, pancortin, gliomedin and mycocilin. These proteins are implicated in the development of the nervous system. Specifically, OLFM1 and OLFM2 expression is observed in the neural plate and neural crest, as well as in the cranial ganglia in mouse at E8-10, and later in brain tissue and in the zone of polarizing activity in the limb. Overexpression of OLFM1 causes an excess of neural crest emigrations and prolonged neural crest production. OLFM2 participates in the regulation of the development of the anterior nervous system. An Arg144Gln mutation in OLFM2 has been implicated as a possible cause for open-angle glaucoma (OAG).

Applications:

WB, IHC

Name of antibody:

OLFM1

Immunogen:

Fusion protein of human OLFM1

Full name:

olfactomedin 1

Synonyms：

OLFM1; NOELIN1; AMY; olfactomedin 1; NOE1; Noelin

SwissProt:

Q99784

IHC positive control:

Human lung cancer

IHC Recommend dilution:

50-200

WB Predicted band size:

55 kDa

WB Positive control:

Brain tissue; MCF7, A549 and SW480 cells

WB Recommended dilution:

500-2000