关键词 |
一抗 |
面向地区 |
剂型 |
其他 |
中文名称： 兔抗KRCC1多克隆抗体
英文名称：Anti-KRCC1 rabbit polyclonal antibody
别 名：lysine rich coiled-coil 1; CHBP2
相关类别：一抗
储 存：冷冻（-20℃）
宿 主：Rabbit
抗 原：KRCC1
反应种属：Human, Mouse
标记物：Unconjugate
克隆类型：rabbit polyclonal
技术规格
Background: | The 21 kDa guanine-nucleotide binding proteins (K-Ras, H-Ras, and N-Ras) cycle between active (GTP-bound) and inactive (GDP-bound) forms. Receptor tyrosine kinases and G protein-coupled receptors activate Ras, which then stimulates the Raf-MEK-MAPK pathway. GTPase-activating proteins (GAP) normally facilitate the inactivation of Ras. However, research studies have shown that in 30% of human tumors, point mutations in Ras prevent the GAP-mediated inhibition of this pathway. The most common oncogenic Ras mutation found in tumors is Gly12 to Asp12 (G12D), which prevents Ras inactivation, possibly by increasing the overall rigidity of the protein. |
Applications: | WB |
Name of antibody: | KRAS |
Immunogen: | Fusion protein of human KRAS |
Full name: | v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog |
Synonyms： | KRAS; C-K-RAS; K-RAS2A; K-RAS2B; K-RAS4A; K-RAS4B; KI-RAS; KRAS1; KRAS2; NS3; RASK2 |
SwissProt: | P01116 |
WB Predicted band size: | 21 kDa |
WB Positive control: | Brain tissue |
WB Recommended dilution: | 500-2000 |
盐城本地兔抗KRCC1热销信息
