兔抗LIMS1多克隆抗体

Background:

The protein encoded by this gene is an adaptor protein which contains five LIM domains, or double zinc fingers. The protein is likely involved in integrin signaling through its LIM domain-mediated interaction with integrin-linked kinase, found in focal adhesion plaques. It is also thought to act as a bridge linking integrin-linked kinase to NCK adaptor protein 2, which is involved in growth factor receptor kinase signaling pathways. Its localization to the periphery of spreading cells also suggests that this protein may play a role in integrin-mediated cell adhesion or spreading. Several transcript variants encoding different isoforms have been found for this gene.

Applications:

ELISA, WB, IHC

Name of antibody:

LIMS1

Immunogen:

Fusion protein of human LIMS1

Full name:

LIM and senescent cell antigen-like domains 1

Synonyms：

PINCH; PINCH1; PINCH-1

SwissProt:

P48059

ELISA Recommended dilution:

2000-5000

IHC positive control:

Human colon cancer and human tonsil

IHC Recommend dilution:

50-200

WB Predicted band size:

37 kDa

WB Positive control:

Human kidney and mouse lung tissue

WB Recommended dilution:

500-2000